| Termijn | Thuis | Uitteam | Uitslag |
|---|---|---|---|
| 2-10-25 18:45 | Rayo Vallecano | KF Shkendija | -:- |
| 2-10-25 18:45 | Jagiellonia Białystok | Hamrun Spartans | -:- |
| 2-10-25 18:45 | Lech Poznan | SK Rapid Wien | -:- |
| 2-10-25 18:45 | Omonia Nicosia | FSV Mainz 05 | -:- |
| 2-10-25 18:45 | FC Noah | HNK Rijeka | -:- |
| 2-10-25 18:45 | FC Lausanne-Sport | Breidablik Kopavogur | -:- |
| 2-10-25 18:45 | HŠK Zrinjski Mostar | Lincoln Red Imps FC | -:- |
| 2-10-25 18:45 | Kuopion PS | KF Drita Gjilan | -:- |
| 2-10-25 18:45 | Dynamo Kiew | Crystal Palace | -:- |
| 2-10-25 21:00 | NK Celje | AEK Athen | -:- |
| 2-10-25 21:00 | FC Shelbourne | BK Häcken | -:- |
| 2-10-25 21:00 | AEK Larnaka | AZ Alkmaar | -:- |
| 2-10-25 21:00 | FC Aberdeen | Schachtjor Donezk | -:- |
| 2-10-25 21:00 | KS Rakow Czestochowa | Universitatea Craiova | -:- |
| 2-10-25 21:00 | Sparta Prag | Shamrock Rovers | -:- |
| 2-10-25 21:00 | SK Slovan Bratislava | Racing Club Strasbourg | -:- |
| 2-10-25 21:00 | Legia Warschau | Samsunspor | -:- |
| 2-10-25 21:00 | AC Florenz | Sigma Olomouc | -:- |